Search for: All records

SARS-CoV-2 infection can result in a range of outcomes from asymptomatic/mild disease to severe COVID-19/fatality. In this study, we investigated the differential expression of small noncoding RNAs (sncRNAs) between patient cohorts defined by disease severity. We collected plasma samples, stratified these based on clinical outcomes, and sequenced their circulating sncRNAs. Excitingly, we found YRNA HY4 displays significant differential expression (p=0.025) between patients experiencing mild and severe disease. In agreement with recent reports identifying plasma YRNAs as indicators of influenza infection severity, our results strongly suggest that circulating HY4 levels represent a powerful prognostic indicator of likely SARS-CoV-2 patient infection outcome. 

Fanfiction presents an opportunity as a data source for research in NLP, education, and social science. However, answering specific research questions with this data is difficult, since fanfiction contains more diverse writing styles than formal fiction. We present a text processing pipeline for fanfiction, with a fo- cus on identifying text associated with characters. The pipeline includes modules for character identification and coreference, as well as the attribution of quotes and narration to those characters. Additionally, the pipeline contains a novel approach to character coreference that uses knowledge from quote attribution to resolve pronouns within quotes. For each module, we evaluate the effectiveness of various approaches on 10 annotated fanfiction stories. This pipeline outperforms tools developed for formal fiction on the tasks of character coreference and quote attribution. 

Abstract The potential of DNA as an information storage medium is rapidly growing due to advances in DNA synthesis and sequencing. However, the chemical stability of DNA challenges the complete erasure of information encoded in DNA sequences. Here, we encode information in a DNA information solution, a mixture of true message- and false message-encoded oligonucleotides, and enables rapid and permanent erasure of information. True messages are differentiated by their hybridization to a "truth marker” oligonucleotide, and only true messages can be read; binding of the truth marker can be effectively randomized even with a brief exposure to the elevated temperature. We show 8 separate bitmap images can be stably encoded and read after storage at 25 °C for 65 days with an average of over 99% correct information recall, which extrapolates to a half-life of over 15 years at 25 °C. Heating to 95 °C for 5 minutes, however, permanently erases the message.